{"id":1127,"date":"2021-12-06T09:51:18","date_gmt":"2021-12-06T09:51:18","guid":{"rendered":"https:\/\/www.creation.hk\/tc\/?p=1127"},"modified":"2024-06-26T07:09:06","modified_gmt":"2024-06-26T07:09:06","slug":"antibiotic-resistance-not-evolution-in-action","status":"publish","type":"post","link":"https:\/\/www.creation.hk\/tc\/antibiotic-resistance-not-evolution-in-action\/","title":{"rendered":"\u6297\u751f\u7d20\u6297\u85e5\u6027 &#8211; \u9032\u884c\u4e2d\u7684\u9032\u5316\uff1f"},"content":{"rendered":"<p> \u6b64\u6587\u7ae0\u520a\u767b\u65bc<a rel=\"noreferrer noopener\" href=\"https:\/\/goo.gl\/forms\/2UKTr6qbVXqLMEvo1\" target=\"_blank\">\u300a\u5275\u9020\u300b\u96dc\u8a8c<\/a>\u7e41\u9ad4\u4e2d\u6587\u7248\u7b2c\u56db\u671f\uff082019\u5e743\u6708\u51fa\u7248\uff09 <\/p><p>\u5510\uff0e\u5df4\u6ed5\uff08 Don Batten\uff09 B.Sc.Agr.\uff08 Hons.\uff09, Ph.D. <\/p><p>\u5df4\u6ed5\u535a\u58eb\u662f\u4e00\u540d\u7814\u7a76\u79d1\u5b78\u5bb6\u548c\u690d\u7269\u751f\u7406\u5b78\u9867\u554f\uff0c\u76ee\u524d\u4efb\u8077\u6fb3\u6d32\u5e03\u91cc\u65af\u672c\u570b\u969b\u5275\u9020\u4e8b\u5de5\u7684\u8ca0\u8cac\u4eba\u3002\u66f4\u591a\u4f5c\u8005\u76f8\u95dc\u8cc7\u8a0a\uff0c\u53c3\u898b\uff1a<a href=\"https:\/\/creation.com\/batten\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">creation.com\/batten<\/a>.<\/p><p>\u6297\u751f\u7d20\u7684\u767c\u73fe\u662f\u91ab\u85e5\u9818\u57df\u4e00\u500b\u6700\u91cd\u5927\u7684\u9032\u5c55\uff0c\u5b83\u5927\u5927\u5730\u6539\u5584\u4e86\u4eba\u985e\u5065\u5eb7\u3002\u904e\u53bb\u5f88\u591a\u81f4\u547d\u7684\u7d30\u83cc\u611f\u67d3\uff08\u5982\u80ba\u7d50\u6838\u548c\u50b7\u53e3\u611f\u67d3\uff09\uff0c\u73fe\u4eca\u90fd\u80fd\u5f97\u5230\u6709\u6548\u6cbb\u7642\uff0c\u633d\u56de\u6578\u4ee5\u767e\u842c\u8a08\u751f\u547d\u3002<\/p><p>\u5728\u6297\u751f\u7d20\u65bc20 \u4e16\u7d0030 \u5e74\u4ee3\u554f\u4e16\u5f8c\u7684\u7d0415 \u5e74\u671f\u9593\uff0c\u6bcf\u5341\u842c\u500b\u7f8e\u570b\u4eba\u7684\u6bcf\u5e74\u6b7b\u4ea1\u7387\u964d\u4f4e\u4e86\u4e8c\u767e\u4e8c\u5341\u4eba\uff0c\u800c\u5176\u4ed6\u6240\u6709\u91ab\u7642\u6280\u8853\u5728\u96a8\u5f8c\u768445 \u5e74\u671f\u9593\uff0c \u6bcf\u5341\u842c\u500b\u7f8e\u570b\u4eba\u7684\u6bcf\u5e74\u6b7b\u4ea1\u7387\u4e5f\u624d\u50c5\u50c5\u964d\u4f4e\u4e86\u4e8c\u5341\u4eba\u3002<sup>1<\/sup> <\/p><p>\u7136\u800c\uff0c\u7d30\u83cc\u51fa\u73fe\u7684\u6297\u85e5\u6027\uff0c\u56b4\u91cd\u5a01\u8105\u9019\u91ab\u85e5\u9818\u57df\u7684\u9032\u5c55\u3002\u5168\u7403\u4f86\u770b\uff0c\u8a31\u591a\u751a\u81f3\u5168\u90e8\u5728\u7528\u7684\u6297\u751f\u7d20\u90fd\u9762\u81e8\u7d30\u83cc\u6297\u85e5\u6027\uff0c\u7531\u6b64\u9020\u6210\u7684\u611f\u67d3\u4e5f\u5728\u4e0d\u65b7\u589e\u52a0\u3002\u6b64\u5916\uff0c\u7814\u88fd\u65b0\u578b\u6297\u751f\u7d20\u7684\u516c\u53f8\u6b63\u5728\u6e1b\u5c11\uff0c1990 \u5e74\u670918 \u9593\u516c\u53f8\uff0c\u800c\u5230\u4e862011 \u5e74\u50c5\u52694 \u9593\u3002<sup>2<\/sup> \u5176\u4e3b\u8981\u539f\u56e0\u662f\u9019\u4e9b\u516c\u53f8\u767c\u73fe\uff0c\u65b0\u7684\u6297\u751f\u7d20\u5728\u6295\u5165\u4f7f\u7528\u5f8c\uff0c\u5c31\u6703\u7acb\u5373\u51fa\u73fe\u6297\u85e5\u6027\uff0c\u800c\u7814\u88fd\u65b0\u578b\u6297\u751f\u7d20\u6210\u672c\u5f88\u9ad8\u3002\u81ea1987 \u5e74\u5f8c\uff0c \u76f4\u52302015 \u5e74\u624d\u6709\u4e00\u6b3e\u65b0\u7814\u767c\u7684\u6297\u751f\u7d20\u54c1\u7a2e\u9762\u4e16\u3002<sup>3<\/sup> <\/p><p>\u5b78\u6821\u548c\u5927\u5b78\u7528\u7684\u751f\u7269\u5b78\u8ab2\u672c\uff0c\u5f80\u5f80\u8868\u9054\u6297\u751f\u7d20\u6297\u85e5\u6027\u662f\u300c\u9032\u884c\u4e2d\u7684\u9032\u5316\u300d\uff08evolution in action\uff09\u4f8b\u5b50\uff0c\u9019\u5047\u8a2d\u63a8\u8ad6\u8b49\u660e\u5fae\u751f\u7269\u53ef\u4ee5\u5728\u6578\u5104\u5e74\u9593\u8b8a\u6210\u751f\u7269\u5b78\u5bb6\u3002\u7136\u800c\uff0c\u5c0d\u6297\u85e5\u6027\u80cc\u5f8c\u7684\u751f\u5316\u6a5f\u5236\u7814\u7a76\u8868\u660e\uff0c\u6297\u85e5\u6027\u7684\u7522\u751f\u4e26\u4e0d\u652f\u6301\u9019\u7a2e\u300c\u5ee3\u7fa9\u9032\u5316\u300d\uff08\u5f9e\u5fae\u751f\u7269\u5230\u4eba\u985e\u7684\u9032\u5316\uff09\u3002\u6297\u85e5\u6027\u6240\u6d89\u53ca\u7684\u6539\u8b8a\u66f4\u652f\u6301\u5275\u9020\u8ad6\u5c0d\u751f\u547d\u7684\u8a8d\u8b58\uff0c\u81ea\u7136\u8b8a\u5316\u662f\u6709\u9650\u7684\uff0c\u4e00\u7a2e\u57fa\u672c\u985e\u578b\u7684\u751f\u7269\uff0c\u7121\u6cd5\u8b8a\u6210\u53e6\u5916\u4e00\u7a2e\u3002<\/p><p><strong>\u6297\u85e5\u6027\u7684\u6a5f\u5236 <\/strong><\/p><p>\u79d1\u5b78\u5bb6\u767c\u73fe\uff0c\u5927\u81f4\u6709\u4e09\u7a2e\u6297\u85e5\u6027\uff1a <\/p><ul class=\"wp-block-list\"><li>\u6297\u751f\u7d20\u7684\u6a19\u9776\u6539\u8b8a\u6216\u88ab\u4fdd\u8b77<\/li><li>\u85e5\u7269\u63a5\u89f8\u6a19\u9776\u7684\u7ba1\u9053\u53d7\u5230\u9650\u5236<\/li><li>\u6297\u751f\u7d20\u7684\u4e0d\u6d3b\u52d5\u6027 <\/li><\/ul><p>1. \u6297\u751f\u7d20\u7684\u6a19\u9776\u6539\u8b8a\u6216\u88ab\u4fdd\u8b77<\/p><p>\u7c98\u83cc\u7d20\uff08Colistin\uff09\uff08\u6216\u53eb\u591a\u7c98\u83cc\u7d20E\uff0c\u82f1\u6587polymyxin E\uff09\u5c31\u662f\u4e00\u500b\u4f8b\u5b50\u3002\u5728\u9ad4\u5167\uff0c\u7c98\u83cc\u7d20\u662f\u6b63\u96fb\u8377\u5206\u5b50\uff0c\u5b83\u80fd\u8207\u67d0\u4e9b\u4f4d\u65bc\u7d30\u83cc\uff08\u9769\u862d\u6c0f\u9670\u6027\u83cc\uff0c\u82f1\u6587Gram-negative bacteria\uff09\u7d30\u80de\u5916\u819c\u7684\u8ca0\u96fb\u8377\u5206\u5b50\uff08\u8102\u591a\u7cd6\uff0c\u82f1\u6587lipopolysaccharide or LPS\uff09\u7d50\u5408\u3002\u9019\u7a2e\u7d50\u5408\u662f\u6bba\u6b7b\u7d30\u83cc\u7684\u7b2c\u4e00\u500b\u5fc5\u8981\u6b65\u9a5f\u3002\u67d0\u500b\u7279\u5b9a\u7d30\u83cc\u5167\u7684\u7a81\u8b8a\uff0c\u53ef\u4ee5\u963b\u6b62\u8ca0\u96fb\u8377\u8102\u591a\u7cd6\u7684\u7522\u751f\uff0c\u9019\u6a23\u5c31\u80fd\u963b\u6b62\u80fd\u6bba\u6b7b\u7d30\u83cc\u7c98\u83cc\u7d20\u8207\u7d30\u83cc\u7684\u7d50\u5408\u3002<sup>4<\/sup> <\/p><p>\u9084\u6709\u5176\u4ed6\u66f4\u8907\u96dc\u7684\u6a5f\u5236\u4f86\u963b\u6b62\u9019\u7a2e\u7d50\u5408\u3002\u6b63\u96fb\u8377\u7684\u9382\uff08magnesium\uff09\u96e2\u5b50\u8207\u5e36\u8ca0\u96fb\u8377\u7684\u8102\u591a\u7cd6\u7d50\u5408\uff0c\u53ef\u4ee5\u8b93\u9019\u4e9b\u985e\u578b\u7684\u7d30\u83cc\u7684\u7d30\u80de\u819c\u4fdd\u6301\u7a69\u5b9a\u3002\u9382\u7684\u6fc3\u5ea6\u5f88\u4f4e\u6642\uff0c\u7d30\u83cc\u6709\u4e00\u500b\u7cfb\u7d71\uff0c\u6703\u628a\u8ca0\u96fb\u8377\u63a9\u84cb\u8d77\u4f86\uff0c\u4ee5\u4fdd\u6301\u7d30\u83cc\u7d30\u80de\u819c\u7a69\u5b9a\u3002\u7d30\u83cc\u7d30\u80de\u6709\u8abf\u7bc0\u9019\u7a2e\u63a9\u84cb\u6a5f\u5236\u7684\u63a7\u5236\u7cfb\u7d71\uff0c\u8b93\u6a5f\u5236\u50c5\u5728\u5fc5\u8981\u6642\u624d\u958b\u555f\u3002\u7a81\u8b8a\u80fd\u7834\u58de\u9019\u7a2e\u63a7\u5236\u7cfb\u7d71\uff0c\u5c0e\u81f4\u9019\u7a2e\u63a9\u84cb\u6a5f\u5236\u4e0d\u65b7\u8655\u65bc\u958b\u555f\u72c0\u614b\u3002\u7d30\u83cc\u7d30\u80de\u7121\u6cd5\u5c07\u5176\u95dc\u9589\u3002\u66b4\u9732\u7684\u8ca0\u96fb\u8377\u6e1b\u5c11\u4e86\uff0c\u9019\u4e5f\u610f\u5473\u8457\u6297\u751f\u7d20\u7121\u6cd5\u5438\u9644\u5728\u7d30\u83cc\u7d30\u80de\u4e0a\u6bba\u6b7b\u7d30\u83cc\u7d30\u80de\u3002\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u7a81\u8b8a\u7684\u7d30\u83cc\u7d30\u80de\u7576\u4e0d\u518d\u9700\u8981\u8a72\u7cfb\u7d71\u6642\uff0c\u5be6\u5c6c\u6d6a\u8cbb\u8cc7\u6e90\uff0c\u6240\u4ee5\u7d30\u83cc\u5728\u6c92\u6709\u6297\u751f\u7d20\u7684\u60c5\u6cc1\u4e0b\uff0c\u7d30\u83cc\u751f\u5b58\u80fd\u529b\u8f03\u5dee\u3002<\/p><p>\u7121\u8ad6\u4f60\u5f9e\u54ea\u500b\u89d2\u5ea6\u770b\uff0c\u76f8\u95dc\u7684\u7a81\u8b8a\u90fd\u662f\u5c0d\u5df2\u6709\u529f\u80fd\u9032\u884c\u7834\u58de\uff0c\u4e26\u6c92\u6709\u5275\u9020\u65b0\u9176\u548c\u65b0\u86cb\u767d\u8cea\u7684\u65b0\u6a5f\u5236\u3002<\/p><p>2. \u85e5\u7269\u63a5\u89f8\u6a19\u9776\u7684\u7ba1\u9053\u53d7\u5230\u9650\u5236<\/p><p>\u5f88\u591a\u6297\u751f\u7d20\u5fc5\u9808\u9032\u5165\u7d30\u83cc\u5167\u90e8\uff0c\u624d\u80fd\u6bba\u6b7b\u7d30\u83cc\u3002\u6bd4\u5982\u78f7\u9ef4\u7d20\uff08fosfomycin\uff09\u8b93\u7d30\u83cc\u7121\u6cd5\u7522\u751f\u7d30\u83cc\u7d30\u80de\u58c1\u4e00\u500b\u5fc5\u5099\u7684\u95dc\u9375\u7d44\u6210\u90e8\u5206\uff0c\u5f9e\u800c\u6bba\u6b7b\u7d30\u83cc\u3002\u7d30\u83cc\u7684\u7d30\u80de\u58c1\u4e0a\u6709\u4e0d\u540c\u7684\u8f38\u9001\u300c\u6cf5\u300d\uff0c\u7d66\u7d30\u80de\u8f38\u9001\u71df\u990a\u7269\u8cea\u3002\u96d6\u7136\u9019\u4e9b\u8f38\u9001\u88dd\u7f6e\u5c0d\u8f38\u9001\u7684\u7269\u4ef6\u6709\u56b4\u683c\u7be9\u9078\uff0c\u4f46\u78f7\u9ef4\u7d20\u5728\u7d50\u69cb\u4e0a\uff0c\u5f88\u50cf\u7d30\u83cc\u7d30\u80de\u58c1\u901a\u5e38\u8f38\u9001\u7684\u71df\u990a\u7269\u8cea\uff0c\u56e0\u6b64\u80fd\u642d\u4e0a\u9032\u5165\u7d30\u80de\u5167\u3002<\/p><p>\u5c08\u9580\u6307\u63ee\u88fd\u9020\u904b\u8f38\u88dd\u7f6e\u7684\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\uff0c\u6216\u4fc3\u9032\u904b\u8f38\u88dd\u7f6e\u751f\u7522\u7684\u8abf\u7bc0\u57fa\u56e0\u767c\u751f\u7a81\u8b8a\uff0c\u90fd\u6703\u5c0e\u81f4\u904b\u8f38\u88dd\u7f6e\u55aa\u5931\u529f\u80fd\u6216\u4f4e\u6548\u904b\u4f5c\u3002\u9019\u5c31\u610f\u5473\u8457\uff0c\u6bd4\u8f03\u5c11\u6216\u6839\u672c\u6c92\u6709\u80fd\u9032\u5165\u7d30\u80de\u58c1\u7684\u78f7\u9ef4\u7d20\u3002\u9019\u7a2e\u7d30\u80de\u4fbf\u5c0d\u78f7\u9ef4\u7d20\u7522\u751f\u4e86\u6297\u85e5\u6027\u3002<\/p><p>\u9019\u88e1\u7684\u60c5\u6cc1\uff0c\u4f9d\u820a\u662f\u7a81\u8b8a\u7834\u58de\u4e86\u7d30\u80de\u7684\u6b63\u5e38\u529f\u80fd\uff0c\u800c\u6c92\u6709\u5275\u9020\u51fa\u65b0\u7684\u57fa\u56e0\u3001\u86cb\u767d\u8cea\u6216\u9176\u3002\u6297\u85e5\u7d30\u80de\u4e26\u975e\u300c\u6539\u826f\u7684\u65b0\u6a21\u578b\u300d\uff0c\u904b\u8f38\u88dd\u7f6e\u672a\u53d7\u640d\u6216\u7f3a\u5931\u524d\uff0c\u904b\u9001\u591a\u7a2e\u71df\u990a\u7269\u8cea\uff0c\u73fe\u5728\u90fd\u4e0d\u80fd\u904b\u9001\u3002\u56e0\u6b64\u5728\u6c92\u6709\u6297\u751f\u7d20\u7684\u60c5\u6cc1\u4e0b\uff0c\u6613\u611f\u7d30\u83cc\u901a\u5e38\u6bd4\u90a3\u4e9b\u6297\u85e5\u7d30\u83cc\u66f4\u5177\u7af6\u722d\u512a\u52e2\uff0c\u56e0\u800c\u6297\u85e5\u7d30\u83cc\uff0c\u53ea\u4f54\u6574\u500b\u7d30\u83cc\u7e3d\u6578\u7684\u6975\u5c11\u90e8\u5206\u3002  <\/p><p><strong>\u53cd\u5411\u6cf5 <\/strong><\/p><p>\u5f88\u591a\u7a2e\u985e\u7684\u7d30\u83cc\uff0c\u90fd\u6709\u80fd\u5c07\u6bd2\u7d20\u6392\u51fa\u7d30\u80de\u7684\u6cf5\uff0c\u6211\u5011\u7a31\u4e4b\u70ba\u300c\u5916\u6392\u6cf5\u300d\u3002\u9019\u4e9b\u6cf5\u4e5f\u80fd\u628a\u6297\u751f\u7d20\u6392\u51fa\uff0c\u5f9e\u800c\u9632\u6b62\u7d30\u80de\u88ab\u6297\u751f\u7d20\u6bba\u6b7b\u3002\u6d89\u53ca\u5916\u6392\u6cf5\u88fd\u9020\u7684\u57fa\u56e0\u8abf\u7bc0\u5f88\u8907\u96dc\uff0c\u4f46\u9650\u5236\u6cf5\u6578\u91cf\u7684\u8abf\u7bc0\u5668\u82e5\u767c\u751f\u7a81\u8b8a\uff0c\u5c31\u6703\u5c0e\u81f4\u7d30\u80de\u88fd\u9020\u66f4\u591a\u7684\u6cf5\uff0c\u5f9e\u800c\u8b93\u7d30\u80de\u5c0d\u6297\u751f\u7d20\u7522\u751f\u6297\u85e5\u6027\u3002\u9019\u7a2e\u6297\u85e5\u7684\u6a21\u5f0f\u5c0d\u6c1f\u55b9\u8afe\u916e\u985e\u6297\u751f\u7d20\uff08fluoroquinolone class of antibiotics\uff09\u5c24\u5176\u95dc\u9375\u3002<sup>5<\/sup> \u9084\u8981\u6ce8\u610f\uff0c \u8abf\u7bc0\u7cfb\u7d71\u88ab\u7834\u58de\u5f8c\uff0c\u7d30\u80de\u6240\u88fd\u9020\u7684\u6cf5\u9060\u8d85\u904e\u5be6\u969b\u6240\u9700\uff0c\u5be6\u5c6c\u8cc7\u6e90\u6d6a\u8cbb\uff0c\u56e0\u6b64\u7a81\u8b8a\u7d30\u80de\u5728\u6c92\u6709\u6297\u751f\u7d20\u7684\u60c5\u6cc1\u4e0b\uff0c\u751f\u547d\u529b\u5c31\u6703\u8b8a\u5f31\u3002\u5728\u9019\u5169\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u7a81\u8b8a\u5728\u300c\u7834\u58de\u300d\u9020\u6cf5\u57fa\u56e0\uff0c\u6216\u5728\u7834\u58de\u8abf\u7bc0\u9020\u6cf5\u7684\u7cfb\u7d71\u3002\u9019\u4e26\u4e0d\u652f\u6301\u7a81\u8b8a\u6703\u5275\u9020\u51fa\u9032\u5316\u8ad6\u6240\u9700\u8981\u7684\u57fa\u56e0\uff0c\u4ee4\u7d30\u83cc\u9032\u5316\u70ba\u7d30\u83cc\u5b78\u5bb6\u3002 <\/p><p>3. \u6297\u751f\u7d20\u7684\u4e0d\u6d3b\u52d5\u6027<\/p><p>\u7d30\u83cc\u5206\u6ccc\u7684\u9176\uff0c\u80fd\u5206\u89e3\uff08\u4ee3\u8b1d\uff09\u6297\u751f\u7d20\u3002\u6bd4\u5982\u540d\u70ba\u03b2- \u5167\u91af\u80fa\u9176\u5c31\u80fd\u5206\u89e3\u76e4\u5c3c\u897f\u6797\uff08penicillins\uff09\u3002\u7d30\u83cc\u9047\u5230\u6297\u751f\u7d20\u5f8c\uff0c\u770b\u4e0a\u53bb\u597d\u50cf\u7372\u5f97\u9019\u6a23\u7684\u80fd\u529b\uff0c\u7522\u751f\u4e00\u7a2e\u65b0\u7684\u9176\uff0c\u4e00\u500b\u65b0\u7684\u57fa\u56e0\uff0c\u9019\u4f3c\u4e4e\u662f\u4e00\u500b\u5f88\u597d\u7684\u9032\u5316\u8ad6\u4f8b\u8b49\u3002\u7136\u800c\u5f9e\u5df2\u77e5\u7684\u60c5\u6cc1\u770b\uff0c\u5f9e\u4f86\u6c92\u6709\u89c0\u5bdf\u5230\u80fd\u62b5\u79a6\u6297\u751f\u7d20\u7684\u9176\u7684\u6a5f\u5236\uff0c\u662f\u7531\u7a81\u8b8a\u7522\u751f\u3002\u90a3\u5b83\u662f\u600e\u9ebc\u51fa\u73fe\u7684\u5462\uff1f<\/p><p><strong>\u57fa\u56e0\u8f49\u79fb <\/strong><\/p><p>\u73fe\u5728\u6211\u5011\u77e5\u9053\uff0c\u7d30\u83cc\u7d30\u80de\u80fd\u5f9e\u5176\u4ed6\u5df2\u6297\u85e5\u7d30\u83cc\u90a3\u88e1\uff0c\u7372\u5f97\u5206\u89e3\u6297\u751f\u7d20\u7684\u80fd\u529b\u3002<\/p><p>\u80fd\u7522\u751f\u6297\u85e5\u6027\u7684\u57fa\u56e0\uff0c\u53ef\u80fd\u4f4d\u65bc\u88ab\u7a31\u70ba\u8cea\u9ad4\uff08plasmids\uff09\u7684DNA \u74b0\u4e0a\uff0c\u800c\u8cea\u9ad4\u4f4d\u65bc\u55ae\u500b\u5713\u5f62\u7d30\u83cc\u67d3\u8272\u9ad4\u7684\u5916\u90e8\u3002\u9019\u4e9b\u8cea\u9ad4\u80fd\u5728\u4e0d\u540c\u7d30\u83cc\u9593\uff0c\u751a\u81f3\u4e0d\u540c\u7269\u7a2e\u9593\u50b3\u905e\u3002<sup>6<\/sup> \u4e00\u7a2e\u6a5f\u5236\u662f\u901a\u904e\u7ba1\u9053\uff08\u83cc\u6bdb\uff09\u628a\u542b\u6709\u548c\u4e0d\u542b\u6297\u85e5\u6027\u8cea\u9ad4\u7684\u5169\u7a2e\u7d30\u83cc\u9023\u63a5\u8d77\u4f86\u3002<sup>7<\/sup> \u6297\u85e5\u83cc\u6703\u8907\u88fd\u9019\u7a2e\u8cea\u9ad4\u4e26\u628a\u8907\u88fd\u54c1\u300c\u6350\u300d\u7d66\u6613\u611f\u67d3\u7d30\u83cc\uff08\u770b\u4e0b\u5716\uff09\u3002<\/p><div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"653\" height=\"505\" data-attachment-id=\"1134\" data-permalink=\"https:\/\/www.creation.hk\/tc\/antibiotic-resistance-not-evolution-in-action\/resistant-donor-recipient\/#main\" data-orig-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?fit=653%2C505&amp;ssl=1\" data-orig-size=\"653,505\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"resistant-donor-recipient\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?fit=300%2C232&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?fit=653%2C505&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?resize=653%2C505&#038;ssl=1\" alt=\"\" class=\"wp-image-1134\" srcset=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?w=653&amp;ssl=1 653w, https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?resize=300%2C232&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/resistant-donor-recipient.jpg?resize=400%2C309&amp;ssl=1 400w\" sizes=\"auto, (max-width: 653px) 100vw, 653px\" \/><\/figure><\/div><p>\u5f88\u591a\u8cea\u9ad4\u90fd\u542b\u6709\u591a\u500b\u91dd\u5c0d\u4e0d\u540c\u7a2e\u985e\u6297\u751f\u7d20\u7684\u6297\u85e5\u57fa\u56e0\u3002<\/p><p>\u6211\u5011\u518d\u6b21\u770b\u5230\uff0c\u9019\u4e00\u985e\u7684\u6297\u85e5\u6027\uff0c \u4e5f\u4e0d\u6d89\u53ca\u65b0\u7684\u57fa\u56e0\uff0c\u53cd\u800c\u662f\u73fe\u6709\u7684\u57fa\u56e0\u5728\u6297\u85e5\u83cc\u7a2e\u548c\u6613\u611f\u67d3\u83cc\u7a2e\u4e4b\u9593\u4e92\u76f8\u50b3\u905e\u3002<sup>8<\/sup> <\/p><div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"391\" height=\"434\" data-attachment-id=\"1133\" data-permalink=\"https:\/\/www.creation.hk\/tc\/antibiotic-resistance-not-evolution-in-action\/chemical-structures\/#main\" data-orig-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?fit=391%2C434&amp;ssl=1\" data-orig-size=\"391,434\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"chemical-structures\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?fit=270%2C300&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?fit=391%2C434&amp;ssl=1\" src=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?resize=391%2C434&#038;ssl=1\" alt=\"\" class=\"wp-image-1133\" srcset=\"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?w=391&amp;ssl=1 391w, https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/chemical-structures.jpg?resize=270%2C300&amp;ssl=1 270w\" sizes=\"auto, (max-width: 391px) 100vw, 391px\" \/><figcaption> <strong>\u5169\u7a2e\u6297\u751f\u7d20\u7684\u5316\u5b78\u7d50\u69cb\uff1a<\/strong>\u76e4\u5c3c\u897f\u6797\uff08\u4e0a\uff09 \u78f7\u9ef4\u7d20\uff08\u4e0b\uff09 <\/figcaption><\/figure><\/div><p><strong>\u7834\u58de\u63a7\u5236\u7cfb\u7d71 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<\/strong><\/p><p>\u5728\u6240\u6709\u9019\u4e9b\u4f8b\u5b50\u4e2d\uff0c\u81ea\u7136\u9078\u64c7\u6703\u504f\u5411\u90a3\u4e9b\u9ad4\u5167\u6709\u5927\u91cf\u6297\u751f\u7d20\u5b58\u5728\u7684\u6297\u85e5\u83cc\u985e\u3002\u7136\u800c\uff0c\u81ea\u7136\u9078\u64c7\u96d6\u7136\u53ef\u4ee5\u89e3\u91cb\u6297\u85e5\u6027\u6709\u5229\u65bc\u751f\u5b58\uff0c\u4f46\u4e0d\u80fd\u89e3\u91cb\u6297\u85e5\u6027\u7684\u8d77\u6e90\u3002\u6297\u85e5\u6027\u5f80\u5f80\u6e90\u81ea\u5c0d\u73fe\u5b58\u7cfb\u7d71\u7684\u4fee\u6539\uff08\u901a\u5e38\u662f\u7834\u58de\uff09\uff0c\u6216\u50b3\u905e\u5df2\u6297\u85e5\u7d30\u83cc\u7684\u57fa\u56e0\u3002\u5728\u81ea\u7136\u74b0\u5883\u4e2d\uff0c\u67d0\u500b\u529f\u80fd\u88ab\u7a81\u8b8a\u7834\u58de\u6642\uff0c\u81ea\u7136\u9078\u64c7\u5f80\u5f80\u6703\u6dd8\u6c70\u6297\u85e5\u83cc\u682a\uff0c\u4f46\u5728\u6709\u5927\u91cf\u6297\u751f\u7d20\u7684\u74b0\u5883\u4e2d\uff0c\u5b83\u5011\u53cd\u800c\u5c0d\u6297\u85e5\u83cc\u682a\u6709\u5229\u3002<\/p><p><strong>\u7d50\u8ad6<\/strong><\/p><p>\u6297\u751f\u7d20\u7684\u6297\u85e5\u6027\u7814\u7a76\u8868\u660e\uff0c\u7a81\u8b8a\u548c\u81ea\u7136\u9078\u64c7\u7684\u4f8b\u5b50\uff0c\u6709\u52a9\u65bc\u7d30\u83cc\u9069\u61c9\uff0c\u5f9e\u800c\u4f7f\u7d30\u83cc\u5728\u6297\u751f\u7d20\u4e0b\u751f\u5b58\u3002\u7136\u800c\uff0c\u9084\u6c92\u6709\u4e00\u500b\u767c\u73fe\u652f\u6301\u73fe\u5b58\u57fa\u56e0\uff08genes\uff09\u6216DNA \u7684\u5076\u7136\u8b8a\u5316\uff08\u7a81\u8b8a\uff09\u7522\u751f\u6578\u5343\u7a2e\u65b0\u57fa\u56e0\u548c\u57fa\u56e0\u7db2\u7d61\uff0c\u4f7f\u5fae\u751f\u7269\u6539\u8b8a\u5230\u4eba\u985e\u3001\u8292\u679c\u548c\u5c0f\u9b1a\u9be8\u7684\u9019\u500b\u89c0\u5ff5\u3002\u5be6\u969b\u4e0a\uff0c\u7814\u7a76\u8868\u660e\u8b8a\u5316\u5f37\u8abf\u4e86\u7a81\u8b8a\u5728\u300c\u5411\u4e0a\u300d\u9032\u5316\u4f5c\u7528\u662f\u6709\u9650\u7684\u3002<\/p><div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><p><strong>\u53c3\u8003\u6587\u737b\u548c\u6ce8\u91cb<\/strong><\/p>\n\n<p>1. Spellberg, B., The antibacterial\npipeline: why it is drying up, and what must be done about it, In: Antibiotic\nResistance: Implications for Global Health and Novel Intervention Strategies:\nWorkshop Summary, National Academies Press, p. 327, 2011. <\/p>\n\n<p>2. Cooper, M.A. and Shlaes, D., Fix\ntheantibiotics pipeline, Nature 472(7341):32, 2011 | doi:10.1038\/472032a. <\/p>\n\n<p>3. Ling, L.L. et al., A new antibiotic\nkills pathogens without detectable resistance, Nature 517(7535): 455\u2013459, 2015\n|doi:10.1038\/ nature14098; the ant ibiot i c is cal l ed teixobactin. <\/p>\n\n<p>4. Moffatt, J.H. et al., Colistin\nresistance in Acinetobacter baumannii is mediated by complete loss of\nlipopolysaccharide production, Antimicrob. Agents Chemother. 54(12):4971\u20137,\n2010 | doi: 10.1128\/ AAC.00834-10. <\/p>\n\n<p>5. Blai r, J.M.A., R i chmond, G . E . ,\nand Piddock, L.J.V., Multidrug efflux pumps in Gramnegative bacteria and their\nrole in antibiotic resistance (review), Future Microbiologym9(10):1165\u20131177,\n2014; | doi:10.2217\/fmb.14.66. <\/p>\n\n<p>6. \u6297\u85e5\u57fa\u56e0\u9084\u6709\u5176\u4ed6\u50b3\u905e\u65b9\u5f0f\uff0c\u5305\u62ec\u566c\u83cc\u9ad4\uff08\u611f\u67d3\u7d30\u83cc\u7684\u75c5\u6bd2\uff09\u3001\u8f49\u5ea7\u5b50\uff08\u5728\u5176\u4ed6\u57fa\u56e0\u5ea7\u4e0a\u8f49\u5ea7\uff09\u548c\u300c\u88f8DNA\u300d\u3002<\/p>\n\n<p>7. \u9019\u7a31\u70ba\u300c\u63a5\u5408\u4f5c\u7528\u300d\uff08conjugation\uff09\u3002<\/p>\n\n<p>8. \u9032\u5316\u8ad6\u8005\u5047\u8a2d\u9019\u4e9b\u57fa\u56e0\uff08\u6bd4\u5982\uff0c\u80fd\u5206\u6ccc\u7834\u58de\u76e4\u5c3c\u897f\u6797\u7684\u03b2-\u5167\u91af\u80fa\u9176\uff09\u6700\u521d\u80af\u5b9a\u662f\u7a81\u8b8a\u7522\u751f\u7684\uff0c\u4f46\u9019\u7a2e\u5047\u8a2d\u548c\u89c0\u6e2c\u4e0d\u7b26\u3002 <\/p>\n\n<p><\/p><\/div><\/div><p> \u672c\u6587\u7d93<a rel=\"noreferrer noopener\" href=\"http:\/\/www.creation.com\/\" target=\"_blank\">\u570b\u969b\u5275\u9020\u4e8b\u5de5\uff08Creation Ministries International\uff09<\/a>\u6388\u6b0a\u8f49\u8f09\uff0c\u539f\u6587\u8acb\u53c3\u7167\uff1a <a href=\"https:\/\/creation.com\/antibiotic-resistance-not-evolution-in-action\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"https:\/\/creation.com\/antibiotic-resistance-not-evolution-in-action (opens in a new tab)\">https:\/\/creation.com\/antibiotic-resistance-not-evolution-in-action<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u6297\u751f\u7d20\u7684\u767c\u73fe\u662f\u91ab\u85e5\u9818\u57df\u4e00\u500b\u6700\u91cd\u5927\u7684\u9032\u5c55\uff0c\u5b83\u5927\u5927\u5730\u6539\u5584\u4e86\u4eba\u985e\u5065\u5eb7\u3002\u904e\u53bb\u5f88\u591a\u81f4\u547d\u7684\u7d30\u83cc\u611f\u67d3\uff08\u5982\u80ba\u7d50\u6838\u548c\u50b7\u53e3\u611f\u67d3\uff09\uff0c\u73fe\u4eca\u90fd\u80fd\u5f97\u5230\u6709\u6548\u6cbb\u7642\uff0c\u633d\u56de\u6578\u4ee5\u767e\u842c\u8a08\u751f\u547d\u3002<\/p>\n","protected":false},"author":2,"featured_media":1137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[7,38,34,28,36],"tags":[208,167,198,193,190,209,196,194,207,200,205,195,201,191,206,204,203,179,202,192,199,197],"class_list":["post-1127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-7","category-38","category-34","category-28","category-36","tag-208","tag-167","tag-198","tag-193","tag-190","tag-209","tag-196","tag-194","tag-207","tag-200","tag-205","tag-195","tag-201","tag-191","tag-206","tag-204","tag-203","tag-179","tag-202","tag-192","tag-199","tag-197","infinite-scroll-item","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-33","no-featured-image-padding"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.creation.hk\/tc\/wp-content\/uploads\/2021\/12\/Antibiotic-resistance-Cover-1.jpg?fit=789%2C526&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paltft-ib","jetpack-related-posts":[],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/posts\/1127","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/comments?post=1127"}],"version-history":[{"count":12,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/posts\/1127\/revisions"}],"predecessor-version":[{"id":1299,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/posts\/1127\/revisions\/1299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/media\/1137"}],"wp:attachment":[{"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/media?parent=1127"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/categories?post=1127"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.creation.hk\/tc\/wp-json\/wp\/v2\/tags?post=1127"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}